Now we come to one of the biggest breakups of the past 20 years, Jennifer Aniston and Brad Pitt. Once upon a time in Hollywood, Aniston and Pitt were Tinseltown's "it" couple. Aniston, the star of one of the most popular sitcoms ever, was America's sweetheart, and Pitt was a serious actor who'd landed on the sexiest man alive list more than once.

The relationship, which seemed like a match made in Hollywood heaven, came to a spectacular, tabloid-worthy end when they divorced amid rumors that Pitt had had an affair with his "Mr. and Mrs. Smith" co-star Angelina Jolie. The rumors turned out to be true, and Pitt and Jolie soon married and started a family, per Glamour. By 2016, they were divorced. Then, in 2021, Pitt and Aniston were photographed chatting backstage at the SAG awards, per E!. Fans were hopeful they might rekindle their romance, but according to expert astrologists, that's never going to happen.

When it comes right down to it, Aniston is an Aquarius, and Pitt is a Sagittarius, two fundamentally different sun signs. According to a report by The Sun, they make great friends, but terrible lovers. Pitt has a fun-loving, impulsive nature which clashes with Aniston's intellectual leanings and private way of life. Long story short, don't hold your breath for a Ross and Rachel-style ending from these two, but chances are Pitt and Aniston will always be friends.